Publications                 Invited Oral Presentations

Publications (since 2006)

47. Niu, F.^$, Shaw, N. ^$, Wang, Y. ^$, Jiao, L. ^$, Ding, W., Li, X., Zhu, P., Upur, H., OuYang, S*, Cheng, G*, and Liu, Z. J*, (2013) Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation, PNAS, doi: 10.1073/pnas.1300035110. ($: equal contribution)[PDF]

46. Ru, H. ^$, Ni, X. ^$, Zhao, L. ^$, Crowley, C., Ding, W., Hung, L., Shaw, N., Cheng, G*. and Liu, Z. J*, (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Research, doi: 10.1038/cr.2013.52. ($: equal contribution).[PDF]

45. Jiao, L. ^$, OuYang, S. ^$, Liang, M. ^$, Niu, F. ^$, Shaw, N., Wu, W., Ding, W., Jin, C., Peng, Y., Zhu, Y., Zhang, F., Wang, T., Li, C., Zuo, X., Luan, C.*, Li., D.*, and Liu, Z. J*, (2013) Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid protein in Complex with Suramin Reveals Therapeutic Potentials. J. VI, doi: 10.1128/JVI.00672-13. ($: equal contribution)[PDF]

44. Won, E, Xie, Y, Takemoto, C, Chen, L, Liu, Z. J, Wang, B. C, Lee, D, Woo, E, Park, S, Shirouzu, M, Yokoyama, S, Kim, S and Chi, S, (2013) High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26, Acta Cryst D, in press.[PDF]

43. Eremeeva, E.^$, Natashin, P.^$, Song, L., Zhou, Y., Berkel, W., Liu, Z. J*, Vysotski, E*.,  (2013) Oxygen Activation of Apo-obelin–Coelenterazine Complex, Chem BioChem, DOI: 10.1002/cbic.201300002. ($: equal contribution).[PDF]

42. Shaw, N., OuYang, S, and Liu, Z. J*, (2012) Binding of bacterial secondary messenger molecule c di-GMP is a STING operation, Protein Cell 4, 117-129.[PDF]

41.  Parvatiyar, K., Zhang, Z., Teles, R. M., Ouyang, S., Jiang, Y., Iyer, S. S., Zaver, S. A., Schenk, M., Zeng, S., Zhong, W., Liu, Z. J., Modlin, R. L., Liu, Y. J*., and Cheng, G*. (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response, Nat Immunol 13, 1155-1161.[PDF]

40.  Hua, T., Wu, D., Ding, W., Wang, J., Neil, N*., and Liu, Z. J*, (2012) Studies on human 2, 4 dienoyl CoA reductase (DCR) sheds new light on peroxisomal β-oxidation of unsaturated fatty acids, J Biol Chem, 287(34):28956-65.[PDF]

39.  OuYang, S, Song, X, Wang, Y, Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parvatiyar, K., Li, Y., Zhang, R., Cheng, G*., and Liu, Z. J*, (2012) Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding, Immunity, 36(6): 1073-1086.[PDF]

38. Zhan, Z^$., Ouyang, S^$., Liang, W., Zhang, Z., Liu, Z. J* and Huang, L.*, (2012) Structural and functional characterization of the C-terminal catalytic domain of the SSV1 integrase. Acta Cryst. D68, 659-670. 2012 May 17. ($: equal contribution) [PDF]

37. Ouyang, S^$, Gong, B^$., Li, J^$., Zhao, L^$., Li, C., Wang, S., Pan, M., Liang, W., Shaw, N., Wu, W., Zhang, F., Sun, L., Zheng, J., Zhao, G., Wang, Y.*, Liu, Z. J.*, Liang, M.*.(2012) Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus. J Mol Med (Berl). 2012 Feb 4.  DOI:10.1007/s00109-012-0866-3. ($: equal contribution) [PDF]

36．Ru, H.^$, Zhao, L.^$, Ding, W.^$, Jiao, L., Shaw, N., Liang, W., Zhang, L., Hung, L., Matsugaki, N., Wakatsuki, S. and Liu, Z. J*, (2012) The S-SAD phasing study of DR6 and its solution conformation revealed by SAXS. Acta Cryst D68, 521-530.($: equal contribution)  [PDF]

35．Cheng, C., Shaw, N., Zhang, X. Zhang, M., Ding, W., Wang, BC & Liu, Z. J*. (2012) Structural view of a non Pfam singleton and crystal packing analysis. PLoS ONE, 7(2): e31673. doi:10.1371. [PDF]

34．Yoshikawa, S., Kukimoto-Niino, M., Parker, L., Handa, N., Terada, T., Fujimoto, T., Terazawa, Y., Wakiyama, M., Sato, M., Sano, S., Kobayashi, T., Tanaka, T., Chen, L., Liu, Z. J., Wang, B. C., Shirouzu, M., Kawa, S., Semba, K., Yamamoto, T., Yokoyama, S. (2012) Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor, Oncogene, 10.1038/onc.2012.21.  [PDF]

33．Titushin, M., Feng, Y., Lee, J., Vysotski, E. & Liu, Z. J*. (2011) Protein-protein complexation in bioluminescence. Protein & Cell, 2(12): 957-972.  [PDF]

32．Liu, Z. J*, Chen, L., Wu, D., Ding, W., Zhang H., Zhou, W., Fu, Z. & Wang, BC*, (2011) A multi-dataset data-collection strategy produces better diffraction data. Acta Cryst A67, 544-549.  [PDF]

31．Liang W^$, Ouyang SY^$, Shaw N, Joachimiak A, Zhang R, Liu ZJ. Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE. FASEB J. 2011 Feb;25(2):497-504. Epub 2010 Oct 5. ($: equal contribution)  [PDF]

30．Titushin, M.^$, Feng, Y^.$, Stepanyuk, G., Li, Y., Markova, S, Golz, S., Wang, BC, Lee, J., Wang, J., Vysotski, E. & Liu, Z. J*. (2010) NMR derived topology of a GFP-photoprotein energy transfer complex. J Biol Chem, 285(52): 40891–40900. ($: equal contribution)  [PDF]

29. Zhou, Y., Shaw, N., Li, Y., Zhao, Y, Zhang, RG, & Liu, Z. J*. (2010) Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules. Faseb J., 24(12): 4668-4677. [PDF]

28. Su, J., Li, Y., Shaw, N., Zhou, WH, Zhang, M., Xu, H., Wang, BC, & Liu, Z. J*. (2010) Crystal structure of a novel non-Pfam protein PF2046 solved using low resolution B-factor sharpening and multi-crystal averaging methods. Protein & Cell, 1(5): 453–458. [PDF]

27. Wu, D., Li, Y., Song, GJ, Zhang, R., Joachimiak, A., Shaw, N., & Liu, Z. J*. (2009) Structural basis for the inhibition of human MTHFS by N10-substituted folate analogues. Cancer Research, 69(18), 7294-301. (Cover) [PDF]

26. Wu, D., Li, Y., Song, GJ, Shaw, N., & Liu, Z. J*. (2009) Crystal structure of human esterase D: a potential genetic marker of retinoblastoma. Faseb J., 23(5), 1441-1446. [PDF]

25. Yin, J., L. Li, N. Shaw, Y. Li, J. K. Song, W. Zhang, C. Xia, R. Zhang, A. Joachimiak, H. C. Zhang, L. X. Wang, Liu, Z. J*, and P. Wang, (2009) Structural Basis and Catalytic Mechanism for the Dual Functional Endo-beta-N-Acetylglucosaminidase A. PLoS ONE, 4(3), e4658   [PDF]

24. Stepanyuk, G.A., Liu, Z. J*, Vysotski, E.S., Lee, Rose, J. and Wang, B.C. (2009). Structure based mechanism of the Ca2+-induced release of coelenterazine from the Renilla binding protein. Proteins, 74(3), 583-93   [PDF]

23. Song, G., Li, Y., Cheng, C., Zhao, Y., Gao, A., Zhang, R., Joachimiak, A., Shaw, N., & Liu, Z. J*. (2009) Structural insight into acute intermittent porphyria. Faseb J., 23(2), 396-404.   [PDF]

22. Wang H, Takemoto C, Akasaka R, Uchikubo-Kamo T, Kishishita S, Murayama K, Terada T, Chen L, Liu Z. J, Wang BC, Sugano S, Tanaka A, Inoue M, Kigawa T, Shirouzu M, Yokoyama S., (2009) Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator. J Struct Biol, 166(1):32-7. [PDF]

21. Stepanyuk, G.A., Liu, Z. J*, Markova, S.V., L A. Frank，Vysotski, E.S., Lee, and Wang, B.C. (2008). Crystal structure of coelenterazine-binding protein from Renilla muelleri at 1.7 Å: Why it is not a calcium-regulated photoprotein. Photochemical & Photobiological Sciences, 7(4), 442–447.  [PDF]

20.  Li, Y., Bahti, P., Shaw, N., Song, G., Cheng, S., Zhang, X., Zhang, M., Cheng, C., Zhu, J., Zhang, H., Che, D., Xu, H., Abbas, A., Wang, B. C. & Liu, Z. J*. (2008) Crystal Structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source. Proteins, 71(4), 2109–2113.  [PDF]

19. Natalia Moiseeva, Robert Bau, Stephen D. Swenson, Francis S. Markland, Jun-Yong Choe, Liu, Z. J and Marc Allaire, (2008) Structure of acostatin, a dimeric disintegrin from Southern copperhead (Agkistrodon contortrix contortrix), at 1.7 Å, Acta Cryst D64, 466–470.  [PDF]

18. Bahti, P., Chen, S., Li, Y., Shaw, N., Zhang, X., Zhang, M., Cheng, C., Song, G., Yin, J., Zhang, H., Che, D., Abbas, A., Xu, H., Wang, B. C. & Liu, Z. J*. (2008) Purification, crystallization and preliminary crystallographic analysis of the non-pfam protein af1514 from archeoglobus fulgidus dsm 4304. Acta Cryst   F, 64(2), 91-93. [PDF]

17. Shaw, N., Tempel, W., Chang, J., Yang, H., Cheng, C., Ng, J., Rose, J., Rao, Z., Wang, B. C. & Liu, Z. J*. (2008) Crystal structure solution of a parb-like nuclease at atomic resolution. Proteins, 70(1), 263-267. [PDF]

16. Shaw, N., Zhao, M., Cheng, C., Xu, H., Saarikettu, J., Li, Y., Da, Y., Yao, Z., Silvennoinen, O., Yang, J., Liu, Z. J*., Wang, B. C. & Rao, Z. (2007) The multifunctional human p100 protein 'hooks' methylated ligands. Nat Struct Mol Biol, 14(8), 779-84. [PDF]

15. Shaw, N., Cheng, C., and Liu, Z. J*, (2007) Procedure for reductive methylation of protein to improve crystallizability. Nature Protocols DOI: 10.1038/nprot.2007.287   [PDF]   

14. Shaw, N., Cheng, C., Tempel, W., Chang, J., Ng, J., Wang, X. Y., Perrett, S., Rose, J., Rao, Z., Wang, B. C. & Liu, Z.J*, (2007). (NZ)CH...O Contacts Assist Crystallization of a Par B –like Nuclease, BMC Struc Biol, 7:46. [PDF]

13. Shimada, A., Niwa, H., Tsujita, K., Suetsugu, S. Kyoko, H.S., Akasaka, R.,Nishino, Y., Toyama, M., Chen, L., Liu, Z.J, Wang, B.C., Yamamoto, M., Terada, T., Miyazawa, A., Shirouzu, M., Tanaka, A., Sugano, S., Takenawa, T., and Yokoyama, S. (2007). Curved EFC/F-BAR domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell, 129, 747-759. [PDF]

12. Liu, Z. J*., Chen, H., Shaw, N., Hopper, S. L., Chen, L., Chen, S., Cerniglia, C. E., and Wang, B. C. (2007), Crystal structure of an aerobic FMN-dependent azoreductase (AzoA) from Enterococcus faecalis. Arch Biochem Biophys, 463, 68-77.  [PDF]

11. Das, A., Fu, Z. Q., Tempel, W., Liu, Z. J.*, Chang, J., Chen, L., Lee, D., Zhou, W., Xu, H., Shaw, N., Rose, J. P., Ljungdahl, L. G., and Wang, B. C. (2007), Characterization of a corrinoid protein involved in the C1 metabolism of strict anaerobic bacterium Moorella thermoacetica. Proteins 67: 167-176. [PDF]

10. Hiyama, T. B., Zhao, M., Kitago, Y., Yao, M., Sekine, S. I., Terada, T., Kuroishi, C., Liu, Z. J., Rose, J. P., Kuramitsu, S., Shirouzu, M., Watanabe, N., Yokoyama, S., Tanaka, I. & Wang, B. C. (2007) Structural basis of coa recognition by the pyrococcus single-domain coa-binding proteins. J Struct Funct Genomics, 7（3-4）: 11. [PDF]

9. Handa, N., Kishishita, S., Morita, S., Akasaka, R., Jin, Z., Chrzas, J., Chen, L., Liu, Z. J., Wang, B. C., Sugano, S., Tanaka, A., Terada, T., Shirouzu, M. & Yokoyama, S. (2007) Structure of the human tim44 c-terminal domain in complex with pentaethylene glycol: Ligand-bound form. Acta Cryst D, 63(12), 1225-1234. [PDF]

8. Gerwe, B., Kelley, L. L., Dillard, B. D., Lai, T., Liu, Z. J., Tempel, W., Chen, L., Habel, J., Lee, D., Jenney, F. E., Jr., Sugar, F. J., Richardson, J. S., Richardson, D. C., Newton, M. G., Wang, B. C., Adams, M. W. & Rose, J. P. (2007) Structural and transcriptional analyses of a purine nucleotide-binding protein from pyrococcus furiosus: A component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon. J Struct Funct Genomics, 8(1), 1-10. [PDF]

7. Kondo, N., Nakagawa, N., Ebihara, A., Chen, L., Liu, Z. J., Wang, B. C., Yokoyama, S., Kuramitsu, S. Masui, R. (2007). Structure of dNTP-inducible dNTP triphosphohydrolase: insight into broad specificity for dNTPs and triphosphohydrolase-type hydrolysis. Acta Cryst D 63, 230-9. [PDF]

6. Kanaujia, S.P., Ranjani, C.V., Jeyakanthan, J., Baba, S., Chen, L., Liu, Z.J., Wang, B.C., Nishida, M., Ebihara, A., Shinkai, A., Kuramitsu, S., Shiro, Y., Sekar, K., and Yokoyama, S. (2007). Crystallization and preliminary crystallographic analysis of molybdenum-cofactor biosynthesis protein C from Thermus thermophilus. Acta Cryst F 63, 27-29. [PDF]

5. Eley, L. L.; Dillard, B. D.; Tempel, W.; Chen, L.; Shaw, N.; Lee, D.; Newton, M. G.; Sugar, F. J.; Jenney, F. E., Jr.; Lee, H. S.; Shah, C.; Poole, F. L., 3rd; Adams, M. W.; Richardson, J. S.; Richardson, D. C.; Liu, Z. J.; Wang, B. C.; Rose, J. (2007). Structure of the hypothetical protein PF0899 from Pyrococcus furiosus at 1.85 Å resolution. Acta Cryst F 63, 549-552. [PDF]

4. Cacciapuoti, G., Porcelli, M., Moretti, M. A., Sorrentino, F., Concilio, L., Zappia, V., Liu, Z. J., Tempel, W., Schubot, F., Rose, J. P., Wang, B. C., Brereton, P. S., Jenney, F. E. & Adams, M. W. (2007) The first agmatine/cadaverine aminopropyl transferase: Biochemical and structural characterization of an enzyme involved in polyamine biosynthesis in the hyperthermophilic archaeon pyrococcus furiosus. J Bacteriol, 189(16), 6057-67. [PDF]

3. Liu, Z.J., Stepanyuk, G.A., Vysotski, E.S., Lee, J., Markova, S.V., Malikova, N.P., and Wang, B.C. (2006). Crystal structure of obelin after Ca2+-triggered bioluminescence suggests neutral coelenteramide as the primary excited state. Proc Natl Acad Sci 103, 2570-2575  [PDF]

2. Powell, A.J., Liu, Z.J., Nicholas, R.A., and Davies, C. (2006). Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding. J Mol Biol 359, 122-136. [PDF]

1. Kuratani, M., Sakai, H., Takahashi, M., Yanagisawa, T., Kobayashi, T., Murayama, K., Chen, L., Liu, Z.J., Wang, B.C., Kuroishi, C., Kuramitsu, S., Terada, T., Bessho, Y., Shirouzu, M., Sekine, S., and Yokoyama, S. (2006). Crystal structures of tyrosyl-tRNA synthetases from Archaea. J Mol Biol 355, 395-408. [PDF]

Invited Oral Presentations(since2006)

35.“Structural basis of innate immune signaling”. 北京协和医院2012第六届过敏性疾病国际高峰论坛，暨首届过敏 – 转化医学峰会, Beijing, China, September 8, 2012.  Zhi-Jie Liu 

34.“ Sulfur-SAD applications: data collection and phasing”, International Workshop on New Developments of Methods and Software for Protein Crystallography, Xi’an, China, August 24, 2012.   Zhi-Jie Liu 

33.“New Tools for S-SAD Phasing”, ACA Annual Meeting, Boston, July 31, 2012.  Zhi-Jie Liu

32.“STING Has a Tail to Tell——Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding”. CSH-Asia Conference-Frontiers of Immunology in Health & Diseases. Suzhou. 2012.09.03-07. Songying Ouyang

31.“接头蛋白STING二聚体形成和c-di-GMP结合的结构基础”, 中国晶体学会第五次全国会员代表大会暨学会议. (The Fifth General Assembly and Academic Congress of Chinese Crystallographic Society (CCrS) 2012)西安. 2012.8.20-23. Songying Ouyang

30.“Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding”, CAS Structural Immunology & Stem Cell Symposium 2012. Kunming, China. 2012.06.30-07.05. Songying Ouyang

29. "The unique dimeric architecture and cyclic di-GMP mediated TBK1 signaling of STING CTD". The China‐U.K. Symposium on Immunity and Health Scientific Program. Beijing. 2012.04.13. Songying Ouyang

28. "X2DF: Parameter Space Screening” method based structure determination pipeline". IBP Youth Forum. Beijing. 2012.3.28. Wei Ding

27. "Protein Crystallography and its Applications”, Siberian Federal University，Krasnoyarsk, Russia, March 2, 2012   Zhi-Jie Liu

26.  “Introduction to Macromolecular Structures”, Siberian Federal University，Krasnoyarsk, Russia, March 1, 2012    Zhi-Jie Liu

25.  “The Evaluation of Sulfur’s Anomalous Signal in Diffraction Data and Beyond”, 4th Winter School on Soft X-Rays in Macromolecular Crystallography，Grenoble, France, February 8, 2012.   Zhi-Jie Liu

24.“Protein-protein complexes in bioluminescence”, The 17th International Biophysics Congress，Beijing, China, November 8, 2011  Zhi-Jie Liu

23."Structural insights into a human anti-IFN antibody exerting therapeutic potential for system lupus erythematosus". CAS Structural Immunology Symposium. Dalian. 2011.07.23-25. Songying Ouyang

22.  “Structural basis of energy transfer in bioluminescent system of jellyfish Clytia and GFP complex”, Nankai-UK Joint Meeting on Membrane Protein Structure and Function，Nankai University, China, May. 11, 2011. Zhi-Jie Liu

21.  “Recent practice on sulfur SAD phasing using soft X-rays”, Workshop on Soft X-ray Crystallography，Chicago, US, May. 4, 2011. Zhi-Jie Liu

20.  “Structural basis for inhibition of interferon alpha signaling pathway and its therapeutic potential in SLE patients”, The Young Scientist Symposium    of IBP，Beijing, China, Jan. 14, 2011. Songying Ouyang

19.  “Structural basis of energy transfer in bioluminescent system of jellyfish Clytia and GFP complex”, The 10th Conference of The Asian Crystallographic Association，Busan, Korea, Oct. 31-Nov. 3, 2010. Maxium Titushin

18.  “Structural basis for the inhibition of human MTHFS by N10-substituted folate analogues”, The 10th Conference of The Asian Crystallographic Association，Busan, Korea, Oct. 31-Nov. 3, 2010. Dong Wu

17.  “How Synchrotron Radiation Facility in Shanghai Aid the Structural Biology Research”, The 160th Eastern Forum of Science & Technology，Shanghai, China, Sept. 16-17, 2010. Zhi-Jie Liu

16. “Structural and Functional Analysis of Calcium Regulated Photoproteins”, PhotoBiology & PhotoBiophysics Symposium，Guiyang, China, Aug. 9, 2010. Zhi-Jie Liu

15. “Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase (MTHFS) by N10-substituted folate analogues”, China-Israel Binational Symposium: Theoretical and Experimental Approaches to Drug Design，Changzhou, China, Mar. 1, 2010. Zhi-Jie Liu

14.  “3D Structure of 5,10-Methenyltetrahydrofolate synthetase (MTHFS) and its application in anti-cancer drugs”, The 199th Yang Scientist Symposium for drug target discovery, Nanjing, China, Sept. 12, 2009. Zhi-Jie Liu

13.  “Data Collection and Structure Analysis”, Cutting-edge methods and techniques in protein research: a workshop for scientists from developing countries, Beijing, China, July 16, 2009. Zhi-Jie Liu

12.  “Excitation coupling in bioluminescence: combined X-ray and NMR determination of the clytin-GFP topology”, The 11th Congress of Biophysical Society of China, Guilin, China, July 15, 2009. Zhi-Jie Liu

11.  “Methylation Assisted Crystallization of Macromolecules”, 6th Annual SER-CAT Symposium at the University of Alabama in Huntsville, March. 20, 2009. Zhi-Jie Liu

10. “Methylation Assisted Crystallization of Protein Molecules”, College of Sciences, Nankai University, March. 6, 2009. Zhi-Jie Liu

9.  “A Structural genomics approach in elucidating the Endo-b-N-acetylglycosaminidase A from Arthrobacter protophormiae”, Uk-China and Chair Symposia, Liverpool, Sept. 25-26, 2008. Zhi-Jie Liu

8. “Crystal structure of coelenterazine-binding protein from Renilla muelleri at 1.72 Å”, The 15th International Symposium on Bioluminescence & Chemiluminescence, Shanghai, May 13-17, 2008. Zhi-Jie Liu

7.  “Multifunctional transcriptional co-activator p100 is involved in splicing: functional and structural basis”, The 6th TICPS International Conference, Shanghai, Nov, 2007. Zhi-Jie Liu

6.  “(NZ)CH…O Contacts Assisted Crystallization”, Asia Crystallography Associate Conference, Taipei, Nov, 2007. Zhi-Jie Liu